Pharmacologic strategies have been advocated to enhance the: neuroreha
bilitation of persons with severe traumatic brain injury. Dopaminergic
pathways have been felt to play a significant role in arousal. Employ
ing single case design methodology we present the case of a survivor o
f severe traumatic brain injury who appeared to have a dose dependent
response to the pro-dopaminergic medication amantadine. Further resear
ch is necessary to clarify the role of pharmacotherapy in the improvem
ent of functional outcome.