FURTHER EVIDENCE FOR A SUSCEPTIBILITY LOCUS ON CHROMOSOME 10P14-P11 IN 72 FAMILIES WITH SCHIZOPHRENIA BY NONPARAMETRIC LINKAGE ANALYSIS

Recent reports on potential linkage by Fara-one and the NIMH Genetics Initiative-Millennium Schizophrenia Consortium [1997: Am J Med Genet 7 4:557], and by Straub et al, [1997: Am J Med Genet 74:558], prompted u s to study chromosome 10 in a sample of 72 families containing 2 or mo re affected sibs with schizophrenia for additional evidence of linkage . We obtained highest allele sharing for the two markers D10S582 (61.5 % allele sharing, chi(2) = 7.61 P = 0.0058) and D10S1423 (59% allele s haring, chi(2) 4.76, P = 0.029), D10S1423 is one of the markers with t he highest lod scores in the study of Faraone and the NIMH Genetics In itiative-Millennium Schizophrenia Consortium [1997: Am J Med Genet 74: 557], GENEHUNTER analysis revealed a nonparametric lod score (NPL) of 3.2 (P = 0.0007) for the marker D10S1714, which lies in the same regio n. Multipoint affected sib-pair lod score analysis (identity by descen t) calculated by ASPEX revealed a lod score of 1.72 for all possible s ib-pair combinations (107) and of 2,13, when only independent sib-pair s (87) were counted, Our study provides further evidence for a potenti al susceptibility locus for schizophrenia on chromosome 10p, Am. J, Me d, Genet, (Neuropsychiatr, Genet,) 81:302-307, 1998, (C) 1998 Wiley-Li ss, Inc.