CLONING AND SEQUENCING OF THE BOVINE STAT5A CDNA REVEALS SIGNIFICANT SEQUENCE DIVERGENCE WITH OVINE

Authors
SCHRODER P MEYER L WHEELER TT THIESEN HJ SEYFERT HM
Citation
P. Schroder et al., CLONING AND SEQUENCING OF THE BOVINE STAT5A CDNA REVEALS SIGNIFICANT SEQUENCE DIVERGENCE WITH OVINE, Biochimica et biophysica acta, N. Gene structure and expression, 1398(2), 1998, pp. 99-105
Citations number
39
Categorie Soggetti
Biology,Biophysics
Journal title
Biochimica et biophysica acta, N. Gene structure and expression → ACNP
ISSN journal
01674781
Volume
1398
Issue
2
Year of publication
1998
Pages
99 - 105
Database
ISI
SICI code
0167-4781(1998)1398:2<99:CASOTB>2.0.ZU;2-Z
Abstract
The transcription factors STAT5 mediates prolactin signals in mammary epithelial cells. The cDNA of bovine STAT5A was cloned, sequenced and compared to other species. The encoded protein proves to be > 95% homo logous to other mammals. We show that the STAT5A mRNA of the closely r elated ovine species contains an extended (by 130 nt) 5'-untranslated region, being encoded by an extra-exon, and accounts, possibly, for im proved translation efficiency. (C) 1998 Elsevier Science B.V. All righ ts reserved.