INFLUENCE OF A BIOLOGICALLY-ACTIVE INTERF ERON FRAGMENT ON THE CARRIER DE-NOVO PROTEIN-STRUCTURE

A biologically active de novo protein albeferon was studied by physica l techniques including CD spectroscopy in far and near ultraviolet reg ions and microcalorimetry. Albeferon was obtained by grafting an activ e octapeptide interferon fragment into a de novo protein albebetin use d as a carrier. It was shown that attachment of the octapeptide into i ts molecule did not weaken albebetin but even slightly improved its st ructure and stability. The obtained results can be used for de novo pr otein design and improvement.