THE DISTRIBUTION OF DIRECT INTERACTIONS I N THE SPATIAL STRUCTURES OFGLOBULAR-PROTEINS

The hydrogen bond distributions in 123 protein structures with the ato m coordinates established at a resolution of less than 2 Angstrom were analyzed. The peculiarities of hydrogen bond distributions with respe ct to the lengths and remoteness of contacting residues in the primary structure were established. A hierarchy of H-bond energy distribution in the spatial structure of protein globules was demonstrated. The ro le of hydrogen bonds in the formation of domain structure and their sp ecial properties in proteins with different types of secondary structu re are discussed.