COMMON PHYSICOCHEMICAL FEATURES OF ENDOGE NOUS HORMONES - LIBERINS AND STATINS

The common chemical features of oligopeptide releasing-hormones and re lease inhibiting hormones were investigated with the aid of computer m ethods. 339 regulatory molecules of such type have been extracted out of data from computer bank EROP-Moscow. They contain from 2 to 47 amin o acid residues and their sequences include short sites, which play ap parently a decisive role in realization of interactions with the recep tors. The analysis of chemical radicals shows that all liberins and st atins contain positively charged group and cyclic radical of some amin o aside or hydrophobic group. Results of this study indicate that the most chemical radicals of hormones are open for the interaction with p otential receptors of target-cells. The mechanism of hormone ligand an d receptors binding and conceivable role of amino acid and neurotransm itter radicals in hormonal properties of liberins and statins is discu ssed.