A. Baroni et al., LIPOTEICHOIC ACID AND PROTEIN-A FROM STAPHYLOCOCCUS-AUREUS STIMULATE RELEASE OF HEPATOCYTE GROWTH-FACTOR (HGF) BY HUMAN DERMAL FIBROBLASTS, Archives of dermatological research, 290(4), 1998, pp. 211-214
In this study we demonstrated that Staphylococcus aureus lipoteichoic
acid (LTA) and protein-A (PA) induce the release from human dermal fib
roblasts of hepatocyte growth factor (HGF), a proliferation factor of
epithelial cells (including keratinocytes). In contrast, LPS and porin
s from Pseudomonas aeruginosa did not stimulate HGF production. Recomb
inant human IL-1 beta induced HGF release. This production was synergi
stically enhanced when in association with LTA (by more than twice) an
d PA (by about two-thirds). Controls were performed in the presence of
bacterial components alone. In previous studies we have shown that LP
S and porins are inducers of IL-1 alpha and beta and other cytokines f
rom human monocytes, Therefore it is possible that in inflammatory cut
aneous foci and infected wounds, bacterial components may induce HGF r
elease from dermal human fibroblasts, LTA and PA act directly, while L
PS and porins act indirectly, through the release of cytokines by mono
cytes/macrophages, HGF plays an important role in the repair of cutane
ous tissue during gram-positive and gram-negative infections.