KETOTIFEN TREATMENT OF ACTIVE COLITIS IN PATIENTS WITH 5-AMINOSALICYLATE INTOLERANCE

Mast cell stabilizers are commonly used in the treatment of asthma and allergic disorders. Although the role of mucosal mast cells in the pa thogenesis of inflammatory bowel disease remains uncertain, mast cell stabilizers have been shown in animal models to attenuate the severity of experimental colitis. The authors' experience with ketotifen in th ree patients one each with Crohn's disease, ulcerative colitis and col lagenous colitis - who had demonstrated allergy to, or intolerance of, 5-aminosalicylic acid is reported.