SYNTHESIS AND DOPAMINE-RECEPTOR SELECTIVITY OF THE BENZYLTETRAHYDROISOQUINOLINE, (R)-(-NOR-ROEFRACTINE())

Authors
CABEDO N PROTAIS P CASSELS BK CORTES D
Citation
N. Cabedo et al., SYNTHESIS AND DOPAMINE-RECEPTOR SELECTIVITY OF THE BENZYLTETRAHYDROISOQUINOLINE, (R)-(-NOR-ROEFRACTINE()), Journal of natural products, 61(6), 1998, pp. 709-712
Citations number
17
Categorie Soggetti
Chemistry Medicinal","Plant Sciences","Pharmacology & Pharmacy",Chemistry
Journal title
Journal of natural products → ACNP
ISSN journal
01633864
Volume
61
Issue
6
Year of publication
1998
Pages
709 - 712
Database
ISI
SICI code
0163-3864(1998)61:6<709:SADSOT>2.0.ZU;2-A
Abstract
(R)-(f)-nor-Roefractine (1) was synthesized by the Bischler-Napieralsk i route, using asymmetric reduction of the 1,2-didehydro precursor imi ne with sodium (S)-N-CBZ-prolinyloxyborohydride. Compound 1 was able t o displace [H-3]-raclopride (a D-2 dopamine receptor-selective ligand) from its specific binding sites in rat striatum with selectivity vs [ H-3]-SCH23390 (D-1 dopamine receptor-selective ligand).