THEONELLAPEPTOLIDE IIIE, A NEW CYCLIC PEPTOLIDE FROM THE NEW-ZEALAND DEEP-WATER SPONGE, LAMELLOMORPHA-STRONGYLATA

Authors
LI SX DUMDEI EJ BLUNT JW MUNRO MHG ROBINSON WT PANNELL LK
Citation
Sx. Li et al., THEONELLAPEPTOLIDE IIIE, A NEW CYCLIC PEPTOLIDE FROM THE NEW-ZEALAND DEEP-WATER SPONGE, LAMELLOMORPHA-STRONGYLATA, Journal of natural products, 61(6), 1998, pp. 724-728
Citations number
15
Categorie Soggetti
Chemistry Medicinal","Plant Sciences","Pharmacology & Pharmacy",Chemistry
Journal title
Journal of natural products → ACNP
ISSN journal
01633864
Volume
61
Issue
6
Year of publication
1998
Pages
724 - 728
Database
ISI
SICI code
0163-3864(1998)61:6<724:TIANCP>2.0.ZU;2-Q
Abstract
The structure, stereochemistry, and conformation of theonellapeptolide IIIe (1), a new 36-membered ring cyclic peptolide from the New Zealan d deep-water sponge Lamellomorpha strongylata, is described. The seque nce of the cytotoxic peptolide was determined through a combination of NMR and MS-MS techniques and confirmed by X-ray crystal structure ana lysis, which, with chiral HPLC, established the absolute stereochemist ry.