MACROCYCLIC DITERPENOIDS FROM EUPHORBIA-SEMIPERFOLIATA

In addition to known compounds, the aerial parts off. semiperfoliata a fforded an abietanolide (3), 13 jatrophane polyesters (4-9, 12, 14-19) , two 4-deoxyphorbol diesters (23, 24), and a pair of epimeric diterpe nes (21, 22) with a novel carbon skeleton, which was named euphoperfol iane. Structures were determined by spectroscopic analysis, and the ma in conformational features of jatropha-6(17),11-dienes are discussed i n detail. The obtained isolation yield of several jatrophanes was unpr ecedented within the spurges (Euphorbia spp.), making E. semiperfoliat a a unique source of macrocyclic diterpenoids.