GLUTATHIONE-MEDIATED METHYLTHIO-TURNOVER AND SEX-DIFFERENCES IN THE METABOLISM OF PENTACHLOROTHIOANISOLE BY RAT

Authors
BAKKE JE MULFORD DJ HUWE JK FEIL VJ DAVISON KL
Citation
Je. Bakke et al., GLUTATHIONE-MEDIATED METHYLTHIO-TURNOVER AND SEX-DIFFERENCES IN THE METABOLISM OF PENTACHLOROTHIOANISOLE BY RAT, Xenobiotica, 23(8), 1993, pp. 949-960
Citations number
23
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Xenobiotica → ACNP
ISSN journal
00498254
Volume
23
Issue
8
Year of publication
1993
Pages
949 - 960
Database
ISI
SICI code
0049-8254(1993)23:8<949:GMASIT>2.0.ZU;2-M
Abstract
1. Sex differences observed in the metabolism of pentachlorothioanisol e in rat were due to: (1) greater excretion in urine by females, and g reater biliary excretion by males; (2) formation of pentachlorophenyl mercapturic acid pathway metabolites by females; and (3) redox-cycling between methylthio and methylsulphoxyl oxidation congeners in interme diary metabolites by females. 2. Three methylthio-turnover processes a re proposed in the intermediary metabolism of pentachlorothioanisole.