FLUORINATED INTERMEDIATES IN THE SYNTHESIS OF BETA-2-FLUORODIDEOXYNUCLEOSIDES

Authors
PATRICK TB YE W
Citation
Tb. Patrick et W. Ye, FLUORINATED INTERMEDIATES IN THE SYNTHESIS OF BETA-2-FLUORODIDEOXYNUCLEOSIDES, Journal of fluorine chemistry, 90(1), 1998, pp. 53-55
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear
Journal title
Journal of fluorine chemistry → ACNP
ISSN journal
00221139
Volume
90
Issue
1
Year of publication
1998
Pages
53 - 55
Database
ISI
SICI code
0022-1139(1998)90:1<53:FIITSO>2.0.ZU;2-3
Abstract
A new and efficient method is described for the preparation of(3S-cis) -3-fluoro-5-[(t-butyldimethylsiloxy) methyl]-2-tetrahydrofuranone (1b) , a valuable intermediate for the synthesis of fluorinated nucleosides . The conversion of 1b to (2,3-dideoxy-2-fluoro-beta-d-threo-pentofura nosyl) thymine (5) is described. (C) 1998 Elsevier Science S.A. All ri ghts reserved.