C. Morand et al., PLASMA METABOLITES OF QUERCETIN AND THEIR ANTIOXIDANT PROPERTIES, American journal of physiology. Regulatory, integrative and comparative physiology, 44(1), 1998, pp. 212-219
Quercetin is one of the most widely distributed flavonoids present in
fruits and vegetables. The present experiments were performed on rats
adapted for 3 wk to a semipurified diet supplemented with 0.2% quercet
in. The major part of the circulating metabolites of quercetin (91.5%)
are glucurono-sulfo conjugates of isorhamnetin (3'-O-methyl quercetin
; 89.1 +/- 2.1 mu M) and of quercetin (14.7 +/- 1.7 mu M); the minor p
art (8.5%) is constituted by glucuronides of quercetin and its methoxy
lated forms (9.6 +/- 2.3 mu M). Conjugated dienes formation, resulting
from Cu2+-catalyzed oxidation of rat very low density lipoproteins low density lipoproteins (LDL), was effectively inhibited in vitro by
conjugated metabolites of quercetin. These metabolites appeared to be
four times more potent than trolox in inhibiting LDL oxidation. Moreov
er, the plasma from rats adapted to a diet containing 0.2% quercetin e
xhibited a total antioxidant status markedly higher than that of contr
ol rats (+ 60%). This study shows that ubiquitous quercetin is conjuga
ted in vivo, yielding metabolites that exhibit antioxidant properties.
Thus the health benefits of flavonoids in foods can be due to the ant
ioxidant properties of their metabolites.