Td. Moody et al., 5-HZ STIMULATION OF CA3 PYRAMIDAL CELL AXONS INDUCES A BETA-ADRENERGIC MODULATED POTENTIATION AT SYNAPSES ON CA1, BUT NOT CA3, PYRAMIDAL CELLS, Brain research, 794(1), 1998, pp. 75-79
In mouse hippocampal slices, long-term potentiation (LTP) at Schaffer
collateral fiber synapses onto CA1 pyramidal cells could be induced by
brief trains of 5-Hz synaptic stimulation (30 s) or by longer trains
of 5-Hz stimulation (3 min) delivered during beta-adrenergic receptor
activation. In contrast, 5-Hz stimulation, either alone or in the pres
ence of the beta-adrenergic receptor agonist isoproterenol, failed to
induce LTP at associational-commissural (assoc-com) fiber synapses ont
o CA3 pyramidal cells. Our results suggest that although CA3 pyramidal
cells give rise to both the Schaffer collateral fiber synapses in CA1
and the assoc-com fiber synapses in CA3, the induction of LTP at thes
e synapses may be regulated by different activity- and modulatory neur
otransmitter-dependent processes. (C) 1998 Elsevier Science B.V.