PREPARATION OF A NOVEL FUNCTIONAL HYDROGEL CONSISTING OF SULFATED GLUCOSIDE-BEARING POLYMER - ACTIVATION OF BASIC FIBROBLAST-GROWTH-FACTOR

Authors
TAGUCHI T KISHIDA A SAKAMOTO N AKASHI M
Citation
T. Taguchi et al., PREPARATION OF A NOVEL FUNCTIONAL HYDROGEL CONSISTING OF SULFATED GLUCOSIDE-BEARING POLYMER - ACTIVATION OF BASIC FIBROBLAST-GROWTH-FACTOR, Journal of biomedical materials research, 41(3), 1998, pp. 386-391
Citations number
27
Categorie Soggetti
Materials Science, Biomaterials","Engineering, Biomedical
Journal title
Journal of biomedical materials research → ACNP
ISSN journal
00219304
Volume
41
Issue
3
Year of publication
1998
Pages
386 - 391
Database
ISI
SICI code
0021-9304(1998)41:3<386:POANFH>2.0.ZU;2-7
Abstract
Sulfated poly(glucosyloxyethyl methacrylate) [poly(GEMA)-sulfate] and its hydrogel were synthesized and evaluated to develop novel tissue re generation assist devices. The poly(GEMA)-sulfate hydrogel was obtaine d by gamma-ray irradiation. Basic fibroblast growth factor (bFGF) was expected to be subsequently incorporated with hydrogel matrices and ac tivated or released from the matrices. A sustained release of bFGF fro m the poly(GEMA)-sulfate hydrogel was not realized; however, bFGF from poly(GEMA)sulfate hydrogel was effectively activated. Poly(GEMA)sulfa te hydrogels are thought to be potential component materials for a tis sue engineering matrix. (C) 1998 John Wiley & Sons, Inc.