ORGAN-SPECIFIC CHEMICAL DIFFERENCES IN GLYCOSMIS-TRICHANTHERA

The lipophilic leaf, stem and root extracts of Glycosmis trichanthera are characterized by distinct chemical profiles, containing sulphur-co ntaining amides in the leaves, prenylated acridone alkaloids in the st em bark, and quinoline alkaloids together with a 3,7-diprenylated indo le in the root bark. Two isomeric sulphones derived from methylhio-pro penoic acid phenethylamides, named trichanthin-A and -B, and the 3,7-d iprenylated indole proved to be new natural products. Structure elucid ation of the new compounds is described by spectroscopic evidence. Bio autographic tests with Cladosporium herbarum showed only moderate anti fungal activity for trichanthin-B and methylgerambullin. (C) 1998 Else vier Science Ltd.All rights reserved.