NEW CYCLOHEXYLIDENEHYDRAZIDE AND 4-AZA-1-THIASPIRO[4.5]DECAN-3-ONE DERIVATIVES OF 3-PHENYL-4(3H)-QUINAZOLINONES

Authors
KARALI N ILHAN E GURSOY A KIRAZ M
Citation
N. Karali et al., NEW CYCLOHEXYLIDENEHYDRAZIDE AND 4-AZA-1-THIASPIRO[4.5]DECAN-3-ONE DERIVATIVES OF 3-PHENYL-4(3H)-QUINAZOLINONES, Il Farmaco, 53(5), 1998, pp. 346-349
Citations number
15
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Il Farmaco → ACNP
ISSN journal
0014827X
Volume
53
Issue
5
Year of publication
1998
Pages
346 - 349
Database
ISI
SICI code
0014-827X(1998)53:5<346:NCA4D>2.0.ZU;2-6
Abstract
In this study, the synthesis of (3-phenyl-4(3H) -quinazolinon-2-yl) me rcaptoacetic acid cyclohexylidenehydrazides and 4-[(3-phenyl-4(3H) -qu inazolinon-2-yl) mercaptoacetylamino] -4-aza-1-thiaspiro [4.5] decan-3 -ones and the results of the study on their antifungal activity are re ported. Most of the tested compounds were found to be active against M icrosporum gypseum NCPF-580, Microsporum canis, Tricophyton mentagroph ytes NCPF-375 var. erinacei and Tricophyton rubrum at 25 mu g/ml. (C) 1998 Elsevier Science S.A. All rights reserved.