DETERMINATION OF ETHYLENEDIAMINETETRAACETIC ACID (EDTA) IN PHARMACEUTICAL DOSAGE FORMS USING FLAME ATOMIC-ABSORPTION SPECTROSCOPY

In this study, flame atomic absorption spectroscopy coupled with the i on-exchange technique was adopted for the determination of ethylenedia minetetraacetic acid (EDTA) in certain dosage forms. The method is bas ed on complexation of EDTA with an excess of calcium(II) or magnesium( II) at pH 10. The remaining metal ions were fixed on a cationic ion- exchange resin, while Ca-EDTA or Mg-EDTA sequestrates were eluted. The eluted sequestrates were determined using flame atomic absorption spe ctroscopy. The experimental conditions were carefully studied, and the method was applied for the determination of EDTA. over the concentrat ion ranges of 4-160 and 2-32 mu g ml(-1) upon using Ca(II) and Mg(II), respectively. The proposed method was successfully applied for the de termination of EDTA in pharmaceutical dosage forms. The proposed metho d is characterized by high sensitivity, satisfactory accuracy and prec ision. (C) 1998 Elsevier Science S.A. All rights reserved.