SYNTHESIS OF SOME NEW PYRIMIDINE AND PYRIDOPYRIMIDINE DERIVATIVES

Authors
DESHMUKH MB SHELAR MA MITTELBACH M JUNEK H
Citation
Mb. Deshmukh et al., SYNTHESIS OF SOME NEW PYRIMIDINE AND PYRIDOPYRIMIDINE DERIVATIVES, Indian journal of chemistry. Sect. B: organic chemistry, including medical chemistry, 37(5), 1998, pp. 491-493
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Indian journal of chemistry. Sect. B: organic chemistry, including medical chemistry → ACNP
ISSN journal
03764699
Volume
37
Issue
5
Year of publication
1998
Pages
491 - 493
Database
ISI
SICI code
0376-4699(1998)37:5<491:SOSNPA>2.0.ZU;2-I
Abstract
The reaction of 2-formyl-3-(dimethylamino) propenenitrile 1 with subst ituted urea give 2-cyano-3-ureido-acrylate 2, which is cyclized under alkaline conditions to yield 5-formyl-4-amino-3-alkyl-2-oxopyrimidine derivatives 3. Treatment of 3 with various substituted hydrazides furn ish the corresponding hydrazones 4a-w. Further, the reaction of 3 with ethyl cyanoacetate in the presence of acetic acid afford desired pyri dopyrimidine 5.