A telepathology study was carried out to examine the differences occur
ring when the images were selected by an experienced pathologist, a ju
nior pathologist and a first-year resident. One hundred and fifty-five
consecutive frozen-section pathology cases were collected and sent fo
r consultation to a remote experienced pathologist using multimedia em
ail. Local diagnoses (as reported in the files of the Institute, not f
rom the image selector) and remote diagnoses (based on the images) wer
e compared with those performed on paraffin-embedded sections. Acquisi
tion time and number of selected images were recorded for each case an
d used to compare the different behaviour of the three local pathologi
sts. Of the 155 cases sent by telepathology, four were considered insu
fficient for a diagnosis by the remote pathologist and thus the diagno
sis was postponed. In the remaining 151 cases, the overall diagnostic
agreement between remote and definitive diagnosis was 96.7%. The resul
ts indicate that in the routine diagnostic work of a frozen-section se
rvice, an inexperienced pathologist can select images which are suffic
iently informative for a remote diagnosis, in a sufficiently short tim
e.