In the past three decades, psychoneuroendocrinologic investigations ha
ve generated a great volume of information, particularly in the field
of affective disorders, which has formed the basis for designing studi
es with newer tools such as anatomic and functional imaging. Ln this a
rticle, the authors focus on endocrine imaging in psychiatry and attem
pt to relate morphometric findings to physiologic neuroendocrine dysfu
nction in depression.