Background Duplex ultrasonography is used increasingly to select patie
nts for carotid endarterectomy. This study aims to clarify whether art
eriography is still required. Methods A total of 272 patients in whom
duplex imaging indicated significant disease of the internal carotid a
rtery underwent arteriography and the results were compared. Regarding
the arteriogram as the 'gold standard', three aspects were considered
: the accuracy of duplex ultrasonography in detecting significant sten
osis, the ability of duplex imaging to identify patients who should ha
ve arteriography and whether the arteriogram provided important additi
onal information that might influence a decision to operate. Results T
hree patients (1 per cent) suffered a permanent neurological deficit a
s a result of arteriography. Of the 272 patients with significant sten
osis identified by duplex ultrasonography, 241 (89 per cent) were conf
irmed as significant on arteriography. Duplex imaging was not able to
predict accurately which arteriograms would provide useful additional
information (sensitivity 59 per cent, specificity 65 per cent), wherea
s 89 arteriograms (33 per cant) contained information that might have
influenced subsequent management. Conclusion Duplex imaging is unable
to detail the anatomy or determine the extent of carotid disease and m
ay therefore lead to an inappropriate decision to perform carotid enda
rterectomy. Duplex imaging alone is not adequate before carotid endart
erectomy.