Purpose. To describe the clinical features. histopathology, surgical m
anagement and possible etiopathogenesis of corneoscleral epithelial cy
sts, Methods. Three patients with corneoscleral epithelial cysts under
went surgical ablation of the cysts. Material obtained during surgery
was subjected to histopathologic analysis. Results. At last follow-up
(mean, 6.3 months), none of the cysts had recurred. All patients had i
mproved visual acuity. Histopathology revealed the occurrence of gland
ular elements suggestive of lacrimal tissue in one of the cysts. Concl
usion. The presence of ectopic lacrimal tissue suggests a developmenta
l etiology for such cysts. Marsupialization of the scleral portion of
the cyst and chemical ablation of the lining epithelium of the corneal
cyst with 20% trichloroacetic acid appears to be a safe and effective
technique in the surgical management of corneoscleral epithelial cyst
s.