ATP SYNTHASE - PAST AND FUTURE

This paper gives an overview of a lecture scheduled for the opening of the 10th European Bioenergetics Congress. In this lecture I plan to f irst reflect on the accomplishments of some of the individuals who wer e involved in research on the ATP synthase during the past 50 years. T hen I will give a brief view of the present information about rotation al catalysis by the ATP synthase. This will be followed by a discussio n of some results from my laboratory that call for additional experime ntation. Finally I will direct attention to other questions about the ATP synthase that should be addressed in future studies. (C) 1998 Else vier Science B.V.