DRUG-DELIVERY SYSTEM FOR THE TREATMENT OF ENDOMETRIAL CARCINOMA

It has been elaborated a polymer system containing medroxyprogesterone acetate (MPA), which is inserted by physicians into the womb in order to release the hormone inside only. The device has a shape of thin ro d of diameter of 4 mm and length of 30 mm. It contains about 350 mg of MPA trapped in poly(ethylene oxide) matrix. The walls of the rod are covered with a few layers of latex, and the final product undergoes ra diation sterilization. The rate of release of MPA to the physiological solution with respect to number of latex layers has been monitored by UV spectroscopy at 240 nm. The results of experiments in vitro have b een compared to those obtained in vivo.