INTRODUCTION - INTEGRINS, DYNAMIC CELL RECEPTORS

Integrins are a family of adhesive receptors consisting of alpha- and beta-subunits which attach cells together via adhesive protein ligands or bind cells to extracellular matrix. They are found on virtually al l cell types and link the external ligand to the cytoskeleton of the c ell. Integrins also act as signal transducers both from the outside of the cell to the interior and also inside-out. Their main functions ar e in recognition and in tight but regulated binding. The series of rev iews presented here cover both basic aspects of integrin function, inc luding signal transduction, snake disintegrins and structure and funct ion of I-domains in some integrin alpha-subunits, as well as the role of integrins in diseases; cancer, inflammation and cardiovascular dise ases. The search for suitable inhibitors of integrins for treatment of these diseases and future prospects for their use are also discussed.