CULTURE SUBSTRATE-SPECIFIC EXPRESSION OF P2Y(2) RECEPTORS IN DISTAL LUNG EPITHELIAL-CELLS ISOLATED FROM FETAL RATS

Authors
CLUNES MT COLLETT A BAINES DL BOVELL DL MURPHIE H INGLIS SK MCALROY HL OLVER RE WILSON SM
Citation
Mt. Clunes et al., CULTURE SUBSTRATE-SPECIFIC EXPRESSION OF P2Y(2) RECEPTORS IN DISTAL LUNG EPITHELIAL-CELLS ISOLATED FROM FETAL RATS, British Journal of Pharmacology, 124(5), 1998, pp. 845-847
Citations number
9
Categorie Soggetti
Pharmacology & Pharmacy",Biology
Journal title
British Journal of Pharmacology → ACNP
ISSN journal
00071188
Volume
124
Issue
5
Year of publication
1998
Pages
845 - 847
Database
ISI
SICI code
0007-1188(1998)124:5<845:CSEOPR>2.0.ZU;2-I
Abstract
ATP and UTP did not evoke [Ca2+](i) signals in rat foetal lung epithel ial cells grown on glass but elicited clear responses in cells grown i nto functionally polarised epithelia on permeable supports. Moreover, P2Y(2) receptor mRNA could not be detected in cells on glass by the po lymerase chain reaction but this mRNA species was clearly expressed by polarised cells. P2Y(2) receptor expression thus appears to be a feat ure of the polarised phenotype.