ACUTE LIVER-FAILURE CAUSED BY ISONIAZID IN A CHILD RECEIVING CARBAMAZEPINE

Authors
BERKOWITZ FE HENDERSON SL FAJMAN N SCHOEN B NAUGHTON N
Citation
Fe. Berkowitz et al., ACUTE LIVER-FAILURE CAUSED BY ISONIAZID IN A CHILD RECEIVING CARBAMAZEPINE, The international journal of tuberculosis and lung disease, 2(7), 1998, pp. 603-606
Citations number
13
Categorie Soggetti
Respiratory System","Infectious Diseases
Journal title
The international journal of tuberculosis and lung disease → ACNP
ISSN journal
10273719
Volume
2
Issue
7
Year of publication
1998
Pages
603 - 606
Database
ISI
SICI code
1027-3719(1998)2:7<603:ALCBII>2.0.ZU;2-3
Abstract
We report a case of a 10-year-old boy, being treated for seizures with carbamazepine, who developed acute liver failure within four days of initiation of therapy for suspected tuberculosis with isoniazid, rifam pin, pyrazinamide, and ethambutol. Isoniazid-induced liver disease was diagnosed. The likely role of carbamazepine and rifampin in potentiat ing the hepatotoxicity of isoniazid, and the importance of early recog nition of isoniazid-induced liver disease, are discussed.