IMMUNE-RESPONSE TO 3 DOSES OF QUADRIVALENT ROTAVIRUS VACCINE - 1-YEARFOLLOW-UP

Twenty-eight children who received three doses of the quadrivalent rot avirus vaccine with 4 x 10(5) plaque-for-ming units (p.f.u.) were foll owed during a year after vaccination. Serum samples were obtained and evaluated for rotavirus IgA and neutralizing antibodies against vaccin e and human rotavirus strains. At the end of the study, up to 61% of t he children showed an increase in circulating IgA antibody levels. Nea rly all of the vaccinated children increased their neutralizing antibo dy titres against the vaccine strains, and 25-54% against human rotavi rus serotypes. After comparing the vaccinees with a population of chil dren naturally infected with serotype G1 in the same study, area, we c onclude that three noses of 4 x 10(5).p.f.u. of the quadrivalent vacci ne should prepare the child against future severe rotavirus diarrhea. (C) 1998 Elsevier Science Ltd. All rights reserved.