S. Levin et Bh. Satir, POLINA - DETECTION AND EVALUATION OF SINGLE AMINO-ACID SUBSTITUTIONS IN PROTEIN SUPERFAMILIES, BIOINFORMATICS, 14(4), 1998, pp. 374-375
Citations number
8
Categorie Soggetti
Computer Science Interdisciplinary Applications","Biology Miscellaneous","Computer Science Interdisciplinary Applications","Biochemical Research Methods
Motivation and results: An algorithm is described for the quick identi
fication and evaluation of amino acid substitutions in multiple protei
n sequence alignment. The strategy is based on the calculation of a re
lative conservation index for an amino acid at each position of the al
ignment. The algorithm is implemented in the computer-program POLINA (
Protein Oriented LINear Analysis) which provides a summary of analysis
in a format suitable for import into a graphing program.