REGULATION OF LDL RECEPTOR GENIC EXPRESSI ON BY TRANSCRIPTION FACTORS

Low density lipoproteins (LDL) are the major transporters of cholester ol in human plasma. Their rapid uptake by specific tissue receptors no rmally limits their atherogenic effects. The expression of these recep tors is controlled by exogenous cholesterol and a variety of sterols w hich act through transcription factors of the Sp-l and SREP (1 and 2) families. The aim of this review is to report on the characterization, role and mechanisms of action of the currently known transcription fa ctors involved in LDL receptor synthesis.