Granuloma inguinale is an indolent, progressive, ulcerative and granul
omatous skin disease caused by Calymmatobacterium granulomatosis. It i
s generally treated with antibiotics. However, long-standing and compl
icated disease requires surgical treatment. Two patients with extensiv
e and multiple perianal fistulas and abscesses unresponsive to medical
treatment were managed with radical surgical resection, The first pat
ient healed by primary intention, but a diverting colostomy was made f
or the second patient and the tissue defect was closed with a rotation
flap, Follow-up at 4 years revealed the disappearance of the symptoms
and the absence of recurrence in both patients.