M. Horiuchi et al., GENOMIC STRUCTURE OF THE BOVINE PRP GENE AND COMPLETE NUCLEOTIDE-SEQUENCE OF BOVINE PRP CDNA, Animal genetics, 29(1), 1998, pp. 37-40
The present authors previously reported the nucleotide sequence of the
5' half of a cDNA encoding bovine prion protein (PrP) and the genomic
structure of the bovine PrP gene encoding the 5'-untranslated region.
Here they report the extent of intron 2 of the bovine PrP gene and th
e nucleotide sequence of the 3' half of bovine PrP cDNA that had not b
een determined before. This newly sequenced 3' half of the bovine PrP
cDNA consisted of 2149 bp. The entire 3'-untranslated region (3'-UTR)
was found to be encoded by a single exon, exon 3. One nucleotide polym
orphism was found in the 3'-UTR. The length of intron 2 was estimated
to be about 14 kbp. The structure of bovine PrP gene can be defined by
combining the present results and previous reports on the bovine PrP
gene.