A NOVEL CHROMIUM TRIOXIDE CATALYZED OXIDATION OF PRIMARY ALCOHOLS TO THE CARBOXYLIC-ACIDS

Authors
ZHAO MZ LI J SONG ZG DESMOND R TSCHAEN DM GRABOWSKI EJJ REIDER PJ
Citation
Mz. Zhao et al., A NOVEL CHROMIUM TRIOXIDE CATALYZED OXIDATION OF PRIMARY ALCOHOLS TO THE CARBOXYLIC-ACIDS, Tetrahedron letters, 39(30), 1998, pp. 5323-5326
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
30
Year of publication
1998
Pages
5323 - 5326
Database
ISI
SICI code
0040-4039(1998)39:30<5323:ANCTCO>2.0.ZU;2-S
Abstract
A novel CrO3 catalyzed oxidation of primary alcohols to the carboxylic acids is reported. The oxidation proceeds smoothly with only 1-2 mol % of CrO3 and 2.5 equivalents of H5IO6 in wet MeCN to give the carboxy lic acids in excellent yield. No significant racemization is observed for alcohols with adjacent chiral centers. Secondary alcohols are clea nly oxidized to ketones. (C) 1998 Elsevier Science Ltd. All rights res erved.