HIGHLY ENANTIOSELECTIVE SYNTHESIS OF CYCLIC AND FUNCTIONALIZED ALPHA-AMINO-ACIDS BY MEANS OF A CHIRAL PHASE-TRANSFER CATALYST

Authors
COREY EJ NOE MC XU F
Citation
Ej. Corey et al., HIGHLY ENANTIOSELECTIVE SYNTHESIS OF CYCLIC AND FUNCTIONALIZED ALPHA-AMINO-ACIDS BY MEANS OF A CHIRAL PHASE-TRANSFER CATALYST, Tetrahedron letters, 39(30), 1998, pp. 5347-5350
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
30
Year of publication
1998
Pages
5347 - 5350
Database
ISI
SICI code
0040-4039(1998)39:30<5347:HESOCA>2.0.ZU;2-5
Abstract
The chiral quaternary ammonium salt 1 serves as phase transfer catalys t for the enantioselective conversion of the glycine derivative 2 to a variety of cyclic and acyclic chiral alpha-amino acids with enantiose lectivities as high as 200:1 in alkylation and Michael addition reacti ons. (C) 1998 Elsevier Science Ltd. All rights reserved.