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Bicyclic nucleoside analogues with a fixed N-type conformation, 2'-O,4
'-C-methyleneuridine and -cytidine, were incorporated into oligonucleo
tides, and the binding efficiency of the modified oligonucleotides to
the complementary DNA and RNA as well as the CD spectra of the modifie
d DNA-DNA and modified DNA-RNA duplexes were studied. (C) 1998 Elsevie
r Science Ltd. All rights reserved.