STABILITY AND STRUCTURAL FEATURES OF THE DUPLEXES CONTAINING NUCLEOSIDE ANALOGS WITH A FIXED N-TYPE CONFORMATION, 2'-O,4'-C-METHYLENERIBONUCLEOSIDES

Citation
S. Obika et al., STABILITY AND STRUCTURAL FEATURES OF THE DUPLEXES CONTAINING NUCLEOSIDE ANALOGS WITH A FIXED N-TYPE CONFORMATION, 2'-O,4'-C-METHYLENERIBONUCLEOSIDES, Tetrahedron letters, 39(30), 1998, pp. 5401-5404
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
ISSN journal
00404039
Volume
39
Issue
30
Year of publication
1998
Pages
5401 - 5404
Database
ISI
SICI code
0040-4039(1998)39:30<5401:SASFOT>2.0.ZU;2-I
Abstract
Bicyclic nucleoside analogues with a fixed N-type conformation, 2'-O,4 '-C-methyleneuridine and -cytidine, were incorporated into oligonucleo tides, and the binding efficiency of the modified oligonucleotides to the complementary DNA and RNA as well as the CD spectra of the modifie d DNA-DNA and modified DNA-RNA duplexes were studied. (C) 1998 Elsevie r Science Ltd. All rights reserved.