J. Khalafy et al., A NEW SYNTHESIS OF CHIRAL AMINOALKYLOXAZOLECARBOXYLATE ESTERS FROM ISOXAZOL-5(2H)-ONES - THE SYNTHESIS OF ALMAZOLE-A AND ALMAZOLE-B, Tetrahedron letters, 39(30), 1998, pp. 5405-5408
2-(1-Aminoalkyl)oxazole-4 and 5-carboxylates are available, without de
tectable racemisation, by a sequence involving N-acylation of isoxazol
-5(2H)one carboxylates with phthalimidoamino acids, photolysis of the
acylated product, and hydrazinolysis. An application of the procedure
to the synthesis of almazole A and B is described (C) 1998 Elsevier Sc
ience Ltd. All rights reserved.