A NEW SYNTHESIS OF CHIRAL AMINOALKYLOXAZOLECARBOXYLATE ESTERS FROM ISOXAZOL-5(2H)-ONES - THE SYNTHESIS OF ALMAZOLE-A AND ALMAZOLE-B

Citation
J. Khalafy et al., A NEW SYNTHESIS OF CHIRAL AMINOALKYLOXAZOLECARBOXYLATE ESTERS FROM ISOXAZOL-5(2H)-ONES - THE SYNTHESIS OF ALMAZOLE-A AND ALMAZOLE-B, Tetrahedron letters, 39(30), 1998, pp. 5405-5408
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
ISSN journal
00404039
Volume
39
Issue
30
Year of publication
1998
Pages
5405 - 5408
Database
ISI
SICI code
0040-4039(1998)39:30<5405:ANSOCA>2.0.ZU;2-Z
Abstract
2-(1-Aminoalkyl)oxazole-4 and 5-carboxylates are available, without de tectable racemisation, by a sequence involving N-acylation of isoxazol -5(2H)one carboxylates with phthalimidoamino acids, photolysis of the acylated product, and hydrazinolysis. An application of the procedure to the synthesis of almazole A and B is described (C) 1998 Elsevier Sc ience Ltd. All rights reserved.