The preparation and use of tissue carriers for processing fragile biol
ogical materials from postfixation up to embedding in electron microsc
opy is described. Trimmed small pieces of vibratome sections can be ve
ry practically and safely transported in these carriers throughout osm
ication, dehydration for long times, and infiltration up to embedding
in epoxy resins. This small device is especially suited for post-embed
ding immunogold electron microscopy.