Pg. Janicak et al., VERAPAMIL FOR THE TREATMENT OF ACUTE MANIA - A DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL, The American journal of psychiatry, 155(7), 1998, pp. 972-973
Objective: This study investigated the efficacy of verapamil in acute
mania. Method: The study was a 3-week double-blind, random-assignment
parallel-group, placebo-controlled inpatient trial of verapamil for pa
tients with acute mania. Of the 32 study patients, 15 were given place
bo and 17 were given verapamil. Results: Mean absolute change scores o
n the Mania Rating Scale at endpoint, with baseline scores as the cova
riates, did not differ between the verapamil and placebo groups. There
were no significant differences between the two groups in age, sex, a
nd presence of psychosis. Conclusions: The investigators found no bene
fit of verapamil over placebo in treating acute mania.