DISRUPTION IN PREPULSE INHIBITION AFTER ALPHA-1-ADRENOCEPTOR STIMULATION IN RATS

Authors
CARASSO BS BAKSHI VP GEYER MA
Citation
Bs. Carasso et al., DISRUPTION IN PREPULSE INHIBITION AFTER ALPHA-1-ADRENOCEPTOR STIMULATION IN RATS, Neuropharmacology, 37(3), 1998, pp. 401-404
Citations number
12
Categorie Soggetti
Pharmacology & Pharmacy",Neurosciences
Journal title
Neuropharmacology → ACNP
ISSN journal
00283908
Volume
37
Issue
3
Year of publication
1998
Pages
401 - 404
Database
ISI
SICI code
0028-3908(1998)37:3<401:DIPIAA>2.0.ZU;2-1
Abstract
The role of the alpha-1 adrenoceptor in prepulse inhibition (PPI) was evaluated in rats. The alpha-1 adrenergic agonist cirazoline disrupted PPI; this effect was reversed by the alpha-1 adrenergic antagonist pr azosin or the atypical antipsychotic quetiapine. Alpha-1 adrenoceptors may thus be involved in the regulation of PPI and in the psychotherap eutic actions of certain antipsychotics. (C) 1998 Elsevier Science Ltd . All rights reserved.