Fifty older persons were interviewed about their medicines, side effec
ts, and their responses to statements describing side effects. Partici
pants were taking nearly 4 drugs each and knew what those medicines we
re and why they were taking them. Participants knew much less about th
e potential side effects and almost nothing about potential drug inter
actions. They wanted to know all the side effects, and indicated that
if their doctors told them about all the side effects, they would stil
l follow the doctors' prescription. However, fewer than 1 in 3 of thei
r doctors were doing so. Responses to hypothetical statements about a
high blood pressure medication showed that positive statements were mo
re reassuring than negative statements. Responses to statements about
side effects were more driven by the nature of the side effect than by
its likelihood. Overall, participants did not find side-effect inform
ation strongly discouraging.