We examined whether a preschool intervention program moderates the eff
ects of perinatal complications with a sample of boys from the most di
sadvantaged areas of Montreal (Canada). Some boys experienced the pres
chool program and some did not, which allowed res to test whether the
program had any effects on the boys' risk for early adolescent delinqu
ency given their perinatal histories. We hypothesized that perinatal c
omplications would place boys at significantly greater risk for antiso
cial behavior during early adolescence and that participation in a pre
ventive preschool program might circumvent this risk. Independent of m
aternal sociodemographic characteristics, boys with a history of perin
atal complications showed no greater risk of reporting delinquency dur
ing early adolescence than their same-sex peeps without a history of p
erinatal complications. Surprisingly, the program showed a beneficial
effect on boys with no history of serious perinatal complications. Suc
h boys were less at risk for delinquency. In the presence of a serious
medical condition after birth, the benefits of the program decreased
significantly to the point that it placed the boys at risk.