THE ROLE OF MIXED MICELLES IN DRUG-DELIVERY - I - SOLUBILIZATION

Citation
Js. Dangi et al., THE ROLE OF MIXED MICELLES IN DRUG-DELIVERY - I - SOLUBILIZATION, Drug development and industrial pharmacy, 24(7), 1998, pp. 681-684
Citations number
15
Categorie Soggetti
Chemistry Medicinal","Pharmacology & Pharmacy
ISSN journal
03639045
Volume
24
Issue
7
Year of publication
1998
Pages
681 - 684
Database
ISI
SICI code
0363-9045(1998)24:7<681:TROMMI>2.0.ZU;2-J
Abstract
The present study revealed that the solubilization of a poorly soluble drug, Amphotericin-B (AmB) can be improved by lipid-bile salt mixed m icelles and it was also noted that mixed micellar systems are thermody namically stable relative to micellar systems. It was observed that th e degradation or precipitation of AmB was significantly reduced when s tored at 8 degrees C. The mixed micellar systems composed of sodium de soxycholate with monoolein increased the solubilization of AmB by more than seven-fold as compared to nonmicellar systems.