The present study revealed that the solubilization of a poorly soluble
drug, Amphotericin-B (AmB) can be improved by lipid-bile salt mixed m
icelles and it was also noted that mixed micellar systems are thermody
namically stable relative to micellar systems. It was observed that th
e degradation or precipitation of AmB was significantly reduced when s
tored at 8 degrees C. The mixed micellar systems composed of sodium de
soxycholate with monoolein increased the solubilization of AmB by more
than seven-fold as compared to nonmicellar systems.