THE ROLE OF MIXED MICELLES IN DRUG-DELIVERY - I - SOLUBILIZATION

The present study revealed that the solubilization of a poorly soluble drug, Amphotericin-B (AmB) can be improved by lipid-bile salt mixed m icelles and it was also noted that mixed micellar systems are thermody namically stable relative to micellar systems. It was observed that th e degradation or precipitation of AmB was significantly reduced when s tored at 8 degrees C. The mixed micellar systems composed of sodium de soxycholate with monoolein increased the solubilization of AmB by more than seven-fold as compared to nonmicellar systems.