U. Cakatay et al., CHANGES IN BONE TURNOVER ON DEOXYPYRIDINOLINE LEVELS IN DIABETIC-PATIENTS, Diabetes research and clinical practice, 40(2), 1998, pp. 75-79
In this study, we evaluated bone turnover in 35 patients with non- ins
ulin-dependent diabetes mellitus with no complications and in 35 healt
hy volunteers who formed the control group and whose ages matched thos
e of the patients. We determined serum osteocalcin (OC) and total alka
line phosphatase levels as markers of bone formation, and urinary deox
ypyridinoline (DPD) and urinary calcium levels as markers of bone reso
rption. Statistical comparison of the levels of these markers between
sexes in diabetic and control groups revealed that the OC levels were
significantly decreased in males and females in the diabetic group com
pared with those of the control group. No significant difference was o
bserved for other markers. It was found that the OC levels of diabetic
subjects were not affected by the type of therapy. No statistically s
ignificant difference was found in serum calcium, phosphorus and magne
sium levels between the diabetic and the control groups. In our study,
the finding that, in spite of the decrease in the OC levels in the di
abetic group no difference was observed in DPD levels, was attributed
to the fact that only the formation phase was affected in diabetes, wh
ile the resorption phase remained unaltered. (C) 1998 Elsevier Science
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