SHARED REGULATORY ELEMENTS IN THE PROMOTERS OF MHC CLASS-I AND CLASS-II GENES

The finding that the major histocompatibility complex (MHC) class II t rans-activator (CIITA) gene product plays a role in the regulation of transcription of MHC class I genes suggests a common regulation of tra nscription of class I and class II genes. Here, Peter van den Elsen an d colleagues argue that the RFX complex also plays a role in the regul ation of transcription of class I genes.