EFFECT OF TRIFLUOPERAZINE, A POTENTIAL-DRUG FOR TUBERCULOSIS WITH PSYCHOTIC DISORDERS, ON THE GROWTH OF CLINICAL ISOLATES OF DRUG-RESISTANTMYCOBACTERIUM-TUBERCULOSIS
Dv. Gadre et al., EFFECT OF TRIFLUOPERAZINE, A POTENTIAL-DRUG FOR TUBERCULOSIS WITH PSYCHOTIC DISORDERS, ON THE GROWTH OF CLINICAL ISOLATES OF DRUG-RESISTANTMYCOBACTERIUM-TUBERCULOSIS, International clinical psychopharmacology, 13(3), 1998, pp. 129-131
The effect of the antipsychotic drug trifluoperazine (TFP) on the in-v
itro growth of 50 clinical isolates of Mycobacterium tuberculosis was
tested. Of these isolates, 29 were susceptible to all five of the anti
tubercular drugs isoniazid, rifampicin, streptomycin, ethambutol and p
yrazinamide, and 21 were resistant to one or more of the five drugs. T
he minimum inhibitory concentration (MIC) of TFP was 4 mu g/ml for 40%
of both the susceptible (12/29) and resistant (8/21) isolates and 8 m
u g/ml for 55% (16/29) and 48% (10/21) of the susceptible and resistan
t isolates respectively. Further analysis of the data for resistant is
olates indicated that the MIC of TFP was 4 mu g/ml and 16 mu g/ml resp
ectively for 50% (4/8) and 75% (6/8) of the isolates resistant to one
drug only from isoniazid, streptomycin or pyrazinamide. Of the nine is
olates resistant to two drugs, isoniazid and streptomycin, the MIC was
4 mu g/ml for 33% (3/9) and 16 mu g/ml for 80% (7/9). The MIC of TFP
for two isolates resistant to the three drugs isoniazid, rifampicin an
d streptomycin was 8 mu g/ml for one and 32 mu g/ml for the other. Of
two isolates resistant to all five drugs, it is of interest to note th
at the MIC of TFP was only 4 mu g/ml for one but 32 mu g/ml for the ot
her. Because the above MICs are for TFP as a single drug, it would be
desirable to study the antitubercular activity of the serum of tubercu
losis patients with psychotic problems receiving regular antitubercula
r therapy supplemented with TFP at its recommended and tolerated dose.
Int Clin Psychopharmacol 13:129-131 (C) 1998 Lippincott-Raven Publish
ers.