HIGH-DOSE CHEMOTHERAPY AND AUTOLOGOUS TRANSPLANTATION IN LYMPHOMATOUSPOLYPOSIS IN 2ND REMISSION - 3 CASE-REPORTS AND LITERATURE-REVIEW

Lymphomatous polyposis is a rare primary gastrointestinal lymphoma. It morphologically and immunohistochemically resembles mantle cell lymph oma, with which it shares a disappointing response rate and duration f ollowing conventional anthracyclin-containing combination chemotherapy , with a short median survival and virtually no long-term survivors, W e report the use of high-dose chemotherapy with autologous stem cell t ransplantation in second partial remission in three patients with lymp homatous polyposis treated at the Royal Marsden Hospital. All patients achieved a complete response, and one patient remains well and diseas e-free 64 months following transplantation and 76 months after diagnos is.