THE ROLE OF DESCENDING BASAL GANGLIA CONNECTIONS TO THE BRAIN-STEM INPARKINSONIAN AKINESIA

Authors
AZIZ TZ DAVIES L STEIN J FRANCE S
Citation
Tz. Aziz et al., THE ROLE OF DESCENDING BASAL GANGLIA CONNECTIONS TO THE BRAIN-STEM INPARKINSONIAN AKINESIA, British journal of neurosurgery, 12(3), 1998, pp. 245-249
Citations number
20
Categorie Soggetti
Clinical Neurology",Surgery
Journal title
British journal of neurosurgery → ACNP
ISSN journal
02688697
Volume
12
Issue
3
Year of publication
1998
Pages
245 - 249
Database
ISI
SICI code
0268-8697(1998)12:3<245:TRODBG>2.0.ZU;2-F
Abstract
Akinesia is the most disabling symptom of Parkinson's disease. The neu ral mechanisms underlying it probably involve the descending projectio ns of the basal ganglia to the brain stem as it improves after a palli dotomy or subthalamic nucleotomy but not after a thalamotomy. We descr ibe the effects of lesioning the pedunculopontine nucleus in the norma l primate in generating an akinetic syndrome. The possible clinical im plications of this study are discussed.