In a consecutive series of 164 patients undergoing primary implantatio
n of an implantable cardioverter defibrillator (ICD), two patients die
d in the hospital (1.2%) and early system infection developed in one p
atient requiring explantation of the device (0.61%). Late infection de
veloped in one additional patient (0.61%) 7 months after transvenous I
CD implantation, and was thought to be due to a recent intravascular c
atheterization. Symptomatic generator pocket hematomas developed in th
ree patients, two of which were treated by simple evacuation and one w
ith temporary generator explantation and subsequent reimplantation of
the unit in a new pocket. No infection developed in these three patien
ts during follow-up. Generator erosion without obvious system infectio
n developed in a fourth patient. Guidelines for the prevention of infe
ction in ICD systems are presented.